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    Effect of Hydration on Healthy Intervertebral Disk Mechanical Stiffness 

    Source: Journal of Biomechanical Engineering:;2015:;volume( 137 ):;issue: 010:;page 101007
    Author(s): Bezci, Semih E.; Nandy, Aditya; O'Connell, Grace D.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The intervertebral disk has an excellent swelling capacity to absorb water, which is thought to be largely due to the high proteoglycan composition. Injury, aging, degeneration, and diurnal loading are all noted by a ...
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    Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics 

    Source: Journal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 005:;page 51004
    Author(s): Yang, Bo; Lu, Yintong; Um, Colin; O'Connell, Grace D.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Aging and degeneration of the intervertebral disk are noted by changes in tissue composition and geometry, including a decrease in nucleus pulposus (NP) area. The NP centroid is positioned slightly posterior of the disk's ...
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    Intervertebral Disc Mechanics With Nucleotomy: Differences Between Simple and Dual Loading 

    Source: Journal of Biomechanical Engineering:;2021:;volume( 143 ):;issue: 008:;page 081002-1
    Author(s): Yang, Bo; Klineberg, Eric; O'Connell, Grace D.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Painful herniated discs are treated surgically by removing extruded nucleus pulposus (NP) material (nucleotomy). NP removal through enzymatic digestion is also commonly performed to initiate degenerative changes to study ...
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    Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics 

    Source: Journal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 005:;page 51004
    Author(s): Yang, Bo; Lu, Yintong; Um, Colin; O'Connell, Grace D.
    Publisher: American Society of Mechanical Engineers (ASME)
    Abstract: Aging and degeneration of the intervertebral disk are noted by changes in tissue composition and geometry, including a decrease in nucleus pulposus (NP) area. The NP centroid is positioned slightly posterior of the disk's ...
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    Torque- and Muscle-Driven Flexion Induce Disparate Risks of In Vitro Herniation: A Multiscale and Multiphasic Structure-Based Finite Element Study 

    Source: Journal of Biomechanical Engineering:;2022:;volume( 144 ):;issue: 006:;page 61005-1
    Author(s): Zhou, Minhao; Huff, Reece D.; Abubakr, Yousuf; O'Connell, Grace D.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The intervertebral disc is a complex structure that experiences multiaxial stresses regularly. Disc failure through herniation is a common cause of lower back pain, which causes reduced mobility and debilitating pain, ...
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    Quantification of Internal Disc Strain Under Dynamic Loading Via High-Frequency Ultrasound 

    Source: Journal of Biomechanical Engineering:;2025:;volume( 147 ):;issue: 003:;page 34501-1
    Author(s): Ghajar-Rahimi, Elnaz; Sakhrani, Diya D.; Kulkarni, Radhika S.; Lim, Shiyin; Dumerer, Blythe; Labine, Annie; Abbott, Michael E.; O'Connell, Grace D.; Goergen, Craig J.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Measurement of internal intervertebral disc strain is paramount for understanding the underlying mechanisms of injury and validating computational models. Although advancements in noninvasive imaging and image processing ...
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