Abstract: Prevention of muscle atrophy caused by reduced mechanical loading in microgravity conditions remains a challenge for longduration spaceflight. To combat leg muscle atrophy, astronauts on the International Space Station ...

Abstract: Patientspecific gait optimizations capable of predicting posttreatment changes in joint motions and loads could improve treatment design for gaitrelated disorders. To maximize potential clinical utility, such optimizations ...

Abstract: Though walking impairments are prevalent in society, clinical treatments are often ineffective at restoring lost function. For this reason, researchers have begun to explore the use of patientspecific computational walking ...

Abstract: Computational walking simulations could facilitate the development of improved treatments for clinical conditions affecting walking ability. Since an effective treatment is likely to change a patient's footground contact ...

Abstract: Accurate prediction of muscle and joint contact forces during human movement could improve treatment planning for disorders such as osteoarthritis, stroke, Parkinson's disease, and cerebral palsy. Recent studies suggest ...

Abstract: Validation is critical if clinicians are to use musculoskeletal models to optimize treatment of individual patients with a variety of musculoskeletal disorders. This paper provides an update on the annual Grand Challenge ...

Abstract: The ability to predict patientspecific joint contact and muscle forces accurately could improve the treatment of walkingrelated disorders. Muscle synergy analysis, which decomposes a large number of muscle electromyographic ...