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Constitutive Modeling of Mouse Arteries Suggests Changes in Directional Coupling and Extracellular Matrix Remodeling That Depend on Artery Type, Age, Sex, and Elastin Amounts
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Arterial stiffening occurs during natural aging, is associated with an increased risk of adverse cardiovascular events, and can follow different timelines in males and females. One mechanism of arterial stiffening includes ...
Elastic Fiber Fragmentation Increases Transmural Hydraulic Conductance and Solute Transport in Mouse Arteries
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Transmural advective transport of solute and fluid was investigated in mouse carotid arteries with either a genetic knockout of fibulin-5 (Fbln5−/−) or treatment with elastase to determine the influence of a disrupted ...
Effects of Increased Arterial Stiffness on Atherosclerotic Plaque Amounts
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Increased arterial stiffness is associated with atherosclerosis in humans, but there have been limited animal studies investigating the relationship between these factors. We bred elastin wildtype (Eln+/+) and heterozygous ...