Journal of Biomechanical Engineering: Recent submissions
Now showing items 781-800 of 5302
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A Thesis Proposal Development Course for Engineering Graduate Students
(The American Society of Mechanical Engineers (ASME), 2020)Helping engineering graduate students to write their thesis can be a difficult and time-consuming undertaking for a thesis advisor. Efficiency can be gained by having an experienced graduate student thesis advisor help ... -
A Six-Year Review of the Biomedical Engineering in Simulations, Imaging, and Modeling Undergraduate Research Experience
(The American Society of Mechanical Engineers (ASME), 2020)Undergraduate research continues to serve as an effective strategy for mitigating the effects of a leaky pipeline. Significant funding from institutions and government agencies has increased the number of students participating ... -
Induced Knockdown of Decorin, Alone and in Tandem With Biglycan Knockdown, Directly Increases Aged Murine Patellar Tendon Viscoelastic Properties
(The American Society of Mechanical Engineers (ASME), 2020)Tendon injuries increase with age, yet the age-associated changes in tendon properties remain unexplained. Decorin and biglycan are two matrix proteoglycans that play complex roles in regulating tendon formation, maturation, ... -
Pregnancy and Lactation Impair Subchondral Bone Leading to Reduced Rat Supraspinatus Tendon-to-Bone Insertion Site Failure Properties
(The American Society of Mechanical Engineers (ASME), 2020)Pregnant women experience weight gain, gait changes, and biochemical fluctuations that impair joint function and alter the maternal skeleton. Hormonal changes increase pelvic ligament laxity in preparation for childbirth ... -
Design as a Feature of Biomedical Engineering Education—Satisfying ABET and Preparing Students to Address Clinical Needs
(The American Society of Mechanical Engineers (ASME), 2020)Design is an important aspect of biomedical engineering education. It prepares students to work as part of a team to develop systems that address medical and health-related needs—and it is required to be part of an accredited ... -
A Mixture Theory Model for Blood Combined With Low-Density Lipoprotein Transport to Predict Early Atherosclerosis Regions in Idealized and Patient-Derived Abdominal Aorta
(The American Society of Mechanical Engineers (ASME), 2020)Genesis and onset of atherosclerosis are greatly influenced by hemodynamic forces. Two-phase transient computational fluid dynamic (CFD) simulations are performed using a mixture theory model for blood, and a transport ... -
Leg Joint Stiffness Affects Dynamics of Backward Falling From Standing Height: A Simulation Work
(The American Society of Mechanical Engineers (ASME), 2020)Falling backward can lead to injuries including hip fracture, back injury, and traumatic brain impact among older adults. A loss of consciousness is associated with falling backward and accounts for about 13% of all falls ... -
Changes in Knee Joint Mechanics After Medial Meniscectomy Determined With a Poromechanical Model
(The American Society of Mechanical Engineers (ASME), 2020)The menisci play a vital role in the mechanical function of knee joint. Unfortunately, meniscal tears often occur. Meniscectomy is a surgical treatment for meniscal tears; however, mechanical changes in the knee joint after ... -
The Effect of Compression Applied Through Constrained Lateral Eccentricity on the Failure Mechanics and Flexibility of the Human Cervical Spine
(The American Society of Mechanical Engineers (ASME), 2020)In contrast to sagittal plane spine biomechanics, little is known about the response of the cervical spine to axial compression with lateral eccentricity of the applied force. This study evaluated the effect of lateral ... -
Knee Kinematics of Healthy Adults Measured Using Biplane Radiography
(The American Society of Mechanical Engineers (ASME), 2020)A dataset of knee kinematics in healthy, uninjured adults is needed to serve as a reference for comparison when evaluating the effects of injury, surgery, rehabilitation, and age. Most currently available datasets that ... -
Investigation of Correction Trajectory Considering Bone End-Plane Orientation and the Shortest Growth Path
(The American Society of Mechanical Engineers (ASME), 2020)External fixators are widely used in orthopedics for the purposes of fracture reduction and bone deformity correction. Since there is nonlinear mapping between the joint and operation spaces of the external fixator, bone ... -
Biomechanical Analysis to Probe Role of Bone Condition and Subject Weight in Stiffness Customization of Femoral Stem for Improved Periprosthetic Biomechanical Response
(The American Society of Mechanical Engineers (ASME), 2020)Stress shielding due to difference in stiffness of bone and implant material is one among the foremost causes of loosening and failure of load-bearing implants. Thus far, femoral geometry has been given priority for the ... -
The Role of Fluid Shear and Metastatic Potential in Breast Cancer Cell Migration
(The American Society of Mechanical Engineers (ASME), 2020)During the migration of cancer cells for metastasis, cancer cells can be exposed to fluid shear conditions. We examined two breast cancer cell lines, MDA-MB-468 (less metastatic) and MDA-MB-231 (more metastatic), and a ... -
Nonlinear Elastic and Inelastic Properties of Cells
(The American Society of Mechanical Engineers (ASME), 2020)Mechanical forces play an important role in various physiological processes, such as morphogenesis, cytokinesis, and migration. Thus, in order to illuminate mechanisms underlying these physiological processes, it is crucial ... -
Mechanobiology of Cartilage Impact Via Real-Time Metabolic Imaging
(The American Society of Mechanical Engineers (ASME), 2020)Cartilage loading is important in both structural and biological contexts, with overloading known to cause osteoarthritis (OA). Cellular metabolism, which can be evaluated through the relative measures of glycolysis and ... -
A Novel Anisotropic Failure Criterion With Dispersed Fiber Orientations for Aortic Tissues
(The American Society of Mechanical Engineers (ASME), 2020)Accurate failure criteria play a fundamental role in biomechanical analyses of aortic wall rupture and dissection. Experimental investigations have demonstrated a significant difference of aortic wall strengths in the ... -
A Microfluidic System to Measure Neonatal Lung Compliance Over Late Stage Development as a Functional Measure of Lung Tissue Mechanics
(The American Society of Mechanical Engineers (ASME), 2020)Premature birth interrupts the development of the lung, resulting in functional deficiencies and the onset of complex pathologies, like bronchopulmonary dysplasia (BPD), that further decrease the functional capabilities ... -
The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, Aging, and Diseases: A Brief Review
(The American Society of Mechanical Engineers (ASME), 2020)Cells sense biophysical cues in the micro-environment and respond to the cues biochemically and biophysically. Proper responses from cells are critical to maintain the homeostasis in the body. Abnormal biophysical cues ... -
A Method to Quantify Tensile Biaxial Properties of Mouse Aortic Valve Leaflets
(The American Society of Mechanical Engineers (ASME), 2020)Understanding aortic valve (AV) mechanics is crucial in elucidating both the mechanisms that drive the manifestation of valvular diseases as well as the development of treatment modalities that target these processes. ... -
Fiber Crimp Confers Matrix Mechanical Nonlinearity, Regulates Endothelial Cell Mechanosensing, and Promotes Microvascular Network Formation
(The American Society of Mechanical Engineers (ASME), 2020)Mechanical interactions between cells and their surrounding extracellular matrix (ECM) guide many fundamental cell behaviors. Native connective tissue consists of highly organized, 3D networks of ECM fibers with complex, ...