| contributor author | Marsh, Jonathan | |
| contributor author | Pidaparti, Ramana M. | |
| date accessioned | 2017-05-09T01:11:13Z | |
| date available | 2017-05-09T01:11:13Z | |
| date issued | 2014 | |
| identifier issn | 1932-6181 | |
| identifier other | med_008_02_021005.pdf | |
| identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/155885 | |
| description abstract | This paper presents an implantable device concept with applications for treating ocular diseases such as glaucoma, agerelated macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa. The design of a biodegradable drug delivery device concept consisting of a polydimethylsiloxane (PDMS) shell with a fluid reservoir and micro/nanofluidic tubes that allow the drug to be stored and delivered at a specified rate is discussed. Computational fluid dynamics simulations were conducted through various tube configurations in order to obtain the drug diffusion characteristics. The results from the simulation studies revealed information related to drug transport under varying design parameters. The design simulations were conducted with a desired rate. Based on results from several simulations, an optimization study was conducted to achieve the required dosage for about 2 years. The results obtained from the optimization study shows that the device concept can be extended for different drugs to treat ocular diseases. | |
| publisher | The American Society of Mechanical Engineers (ASME) | |
| title | Design Optimization of an Implantable Device Concept for Passive Ocular Drug Delivery | |
| type | Journal Paper | |
| journal volume | 8 | |
| journal issue | 2 | |
| journal title | Journal of Medical Devices | |
| identifier doi | 10.1115/1.4026451 | |
| journal fristpage | 21005 | |
| journal lastpage | 21005 | |
| identifier eissn | 1932-619X | |
| tree | Journal of Medical Devices:;2014:;volume( 008 ):;issue: 002 | |
| contenttype | Fulltext | |