Characterization of Bilayer Tissue Moduli and Thickness Via Eccentric Rotating Mass Dynamics

Abstract

Abstract. The peripheral tissues consist of skin and subcutaneous tissue. Their multilayered biomechanical properties serve as key health indicators and are crucial for clinical applications. Flexible electronics offer a promising approach for continuous in vivo monitoring of peripheral tissue biomechanics. However, these methods depend on complex dispersion analysis or extensive experimental data fitting, which limits their practicality. This study develops an analytical model based on an eccentric rotating mass (ERM) motor for direct and simultaneous measurement of the elastic moduli and thickness of the top skin layer of bilayer tissue. The analytical model used to evaluate tissue compliance involves three dimensionless parameters: the modulus ratio between the top and bottom layers, the normalized thickness of the top skin layer, and one parameter related to ERM. Both simulations and experiments confirm the model's accuracy, showing average errors of only 10% in the inverse characterization of bilayer moduli and thickness for representative bilayer tissue phantoms, paving the way for the development of flexible devices for in vivo tissue health monitoring.