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RISTissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Excessive loading of ligaments can activate the neural afferents that innervate the collagenous tissue, leading to a host of pathologies including pain. An integrated experimental and modeling approach was used to define ...
The Interface of Mechanics and Nociception in Joint Pathophysiology: Insights From the Facet and Temporomandibular Joints
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Chronic joint pain is a widespread problem that frequently occurs with aging and trauma. Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and molecular mechanisms contributing to ...
Collagen Organization in Facet Capsular Ligaments Varies With Spinal Region and With Ligament Deformation
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The spinal facet capsular ligament (FCL) is primarily comprised of heterogeneous arrangements of collagen fibers. This complex fibrous structure and its evolution under loading play a critical role in determining the ...