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RISThe Biomechanical Function of Arterial Elastin in Solutes
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Elastin is essential to accommodate physiological deformation and provide elastic support for blood vessels. As a long-lived extracellular matrix protein, elastin can suffer from cumulative effects ...
Obstruction-Induced Pulmonary Vascular Remodeling
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Pulmonary obstruction occurs in many common forms of congenital heart disease. In this study, pulmonary artery (PA) banding is used as a model for pulmonary stenosis. Significant remodeling of ...
Simulations of Congenital Septal Defect Closure and Reactivity Testing in Patient-Specific Models of the Pediatric Pulmonary Vasculature: A 3D Numerical Study With Fluid-Structure Interaction
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Clinical imaging methods are highly effective in the diagnosis of vascular pathologies, but they do not currently provide enough detail to shed light on the cause or progression of such diseases, ...
Application of A Microstructural Constitutive Model of the Pulmonary Artery to Patient-Specific Studies: Validation and Effect of Orthotropy
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: We applied a statistical mechanics based microstructural model of pulmonary artery mechanics, developed from our previous studies of rats with pulmonary arterial hypertension (PAH), to patient-specific ...