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    Untangling the Effect of Head Acceleration on Brain Responses to Blast Waves 

    Source: Journal of Biomechanical Engineering:;2015:;volume( 137 ):;issue: 012:;page 124502
    Author(s): Mao, Haojie; Unnikrishnan, Ginu; Rakesh, Vineet; Reifman, Jaques
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Multiple injurycausing mechanisms, such as wave propagation, skull flexure, cavitation, and head acceleration, have been proposed to explain blastinduced traumatic brain injury (bTBI). An accurate, quantitative description ...
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    Elastic Anisotropy of Trabecular Bone in the Elderly Human Vertebra 

    Source: Journal of Biomechanical Engineering:;2015:;volume( 137 ):;issue: 011:;page 114503
    Author(s): Unnikrishnan, Ginu U.; Gallagher, John A.; Hussein, Amira I.; Barest, Glenn D.; Morgan, Elise F.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Knowledge of the nature of the elastic symmetry of trabecular bone is fundamental to the study of bone adaptation and failure. Previous studies have classified human vertebral trabecular bone as orthotropic or transversely ...
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    Effect of Specimen Specific Anisotropic Material Properties in Quantitative Computed Tomography Based Finite Element Analysis of the Vertebra 

    Source: Journal of Biomechanical Engineering:;2013:;volume( 135 ):;issue: 010:;page 101007
    Author(s): Unnikrishnan, Ginu U.; Barest, Glenn D.; Berry, David B.; Hussein, Amira I.; Morgan, Elise F.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Intraand interspecimen variations in trabecular anisotropy are often ignored in quantitative computed tomography (QCT)based finite element (FE) models of the vertebra. The material properties are typically estimated solely ...
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    An Integrated Musculoskeletal Finite Element Model to Evaluate Effects of Load Carriage on the Tibia During Walking 

    Source: Journal of Biomechanical Engineering:;2016:;volume( 138 ):;issue: 010:;page 101001
    Author(s): Xu, Chun; Silder, Amy; Zhang, Ju; Hughes, Julie; Unnikrishnan, Ginu; Reifman, Jaques; Rakesh, Vineet
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Prior studies have assessed the effects of load carriage on the tibia. Here, we expand on these studies and investigate the effects of load carriage on joint reaction forces (JRFs) and the resulting spatiotemporal stress/strain ...
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    Material Properties of Rat Middle Cerebral Arteries at High Strain Rates 

    Source: Journal of Biomechanical Engineering:;2018:;volume( 140 ):;issue: 007:;page 71004
    Author(s): David Bell, E.; Converse, Matthew; Mao, Haojie; Unnikrishnan, Ginu; Reifman, Jaques; Monson, Kenneth L.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Traumatic brain injury (TBI), resulting from either impact- or nonimpact blast-related mechanisms, is a devastating cause of death and disability. The cerebral blood vessels, which provide critical support for brain tissue ...
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    Differences in Trabecular Microarchitecture and Simplified Boundary Conditions Limit the Accuracy of Quantitative Computed Tomography-Based Finite Element Models of Vertebral Failure 

    Source: Journal of Biomechanical Engineering:;2018:;volume( 140 ):;issue: 002:;page 21004
    Author(s): Hussein, Amira I.; Louzeiro, Daniel T.; Unnikrishnan, Ginu U.; Morgan, Elise F.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Vertebral fractures are common in the elderly, but efforts to reduce their incidence have been hampered by incomplete understanding of the failure processes that are involved. This study's goal was to elucidate failure ...
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    An Analytical Model of Tumors With Higher Permeability Than Surrounding Tissues for Ultrasound Elastography Imaging 

    Source: Journal of Engineering and Science in Medical Diagnostics and Therapy:;2019:;volume( 001 ):;issue: 003:;page 31006
    Author(s): Islam, Md Tauhidul; Chaudhry, Anuj; Unnikrishnan, Ginu; Reddy, J. N.; Righetti, Raffaella
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Cancerous tissues are known to possess different poroelastic properties with respect to normal tissues. Interstitial permeability is one of these properties, and it has been shown to be of diagnostic relevance for the ...
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    Animal Orientation Affects Brain Biomechanical Responses to Blast-Wave Exposure 

    Source: Journal of Biomechanical Engineering:;2021:;volume( 143 ):;issue: 005:;page 051007-1
    Author(s): Unnikrishnan, Ginu; Mao, Haojie; Sajja, Venkata Siva Sai Sujith; van Albert, Stephen; Sundaramurthy, Aravind; Rubio, Jose E.; Subramaniam, Dhananjay Radhakrishnan; Long, Joseph; Reifman, Jaques
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: In this study, we investigated how animal orientation within a shock tube influences the biomechanical responses of the brain and cerebral vasculature of a rat when exposed to a blast wave. Using three-dimensional finite ...
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    A Strain Rate-Dependent Constitutive Model for Göttingen Minipig Cerebral Arteries 

    Source: Journal of Biomechanical Engineering:;2022:;volume( 144 ):;issue: 008:;page 81007-1
    Author(s): Pearson, Noah; Boiczyk, Gregory M.; Kote, Vivek Bhaskar; Sundaramurthy, Aravind; Subramaniam, Dhananjay Radhakrishnan; Rubio, Jose E.; Unnikrishnan, Ginu; Reifman, Jaques; Monson, Kenneth
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Computational simulations of traumatic brain injury (TBI) are commonly used to advance understanding of the injury–pathology relationship, tissue damage thresholds, and design of protective equipment such as helmets. Both ...
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    Rate- and Region-Dependent Mechanical Properties of Göttingen Minipig Brain Tissue in Simple Shear and Unconfined Compression 

    Source: Journal of Biomechanical Engineering:;2023:;volume( 145 ):;issue: 006:;page 61004-1
    Author(s): Boiczyk, Gregory M.; Pearson, Noah; Kote, Vivek Bhaskar; Sundaramurthy, Aravind; Subramaniam, Dhananjay Radhakrishnan; Rubio, Jose E.; Unnikrishnan, Ginu; Reifman, Jaques; Monson, Kenneth L.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Traumatic brain injury (TBI), particularly from explosive blasts, is a major cause of casualties in modern military conflicts. Computational models are an important tool in understanding the underlying biomechanics of TBI ...
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