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A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: A major risk factor for tendinopathy is tendon overuse (i.e., fatigue loading). Fatigue loading of tendon damages the extracellular matrix and induces tissue degeneration. However, the specific mechanisms linking tendon ...
The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Biophysical stimuli presented to cells via microenvironmental properties (e.g., alignment and stiffness) or external forces have a significant impact on cell function and behavior. Recently, the cell nucleus has been ...
The Elephant in the Cell: Nuclear Mechanics and Mechanobiology
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The 2021 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) featured a workshop titled “The Elephant in the Room: Nuclear Mechanics and Mechanobiology.” The goal of this workshop was to provide a ...
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