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RISTissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Excessive loading of ligaments can activate the neural afferents that innervate the collagenous tissue, leading to a host of pathologies including pain. An integrated experimental and modeling approach was used to define ...