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RISEvaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Despite the prevalence of disc degeneration and its contributions to low back problems, many current treatments are palliative only and ultimately fail. To address this, nucleus pulposus replacements are under development. ...
Human Disc Nucleotomy Alters Annulus Fibrosus Mechanics at Both Reference and Compressed Loads
Publisher: American Society of Mechanical Engineers (ASME)
Abstract: Nucleotomy is a common surgical procedure and is also performed in ex vivo mechanical testing to model decreased nucleus pulposus (NP) pressurization that occurs with degeneration. Here, we implement novel and noninvasive ...