Abstract: Cells have evolved into complex sensory machines that communicate with their microenvironment via mechanochemical signaling. Extracellular mechanical cues trigger complex biochemical pathways in the cell, which regulate ...

Abstract: Finite element and machine learning modeling are two predictive paradigms that have rarely been bridged. In this study, we develop a parametric model to generate arterial geometries and accumulate a database of 12,172 2D ...

Abstract: Multiscale coupling between cell-scale biology and tissue-scale mechanics is a promising approach for modeling disease growth. In such models, tissue-level growth and remodeling (G&R) are driven by cell-level signaling ...