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    Anthropomorphic Model of Intrathecal Cerebrospinal Fluid Dynamics Within the Spinal Subarachnoid Space: Spinal Cord Nerve Roots Increase Steady-Streaming 

    Source: Journal of Biomechanical Engineering:;2018:;volume( 140 ):;issue: 008:;page 81012
    Author(s): Khani, Mohammadreza; Sass, Lucas R.; Xing, Tao; Keith Sharp, M.; Balédent, Olivier; Martin, Bryn A.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Cerebrospinal fluid (CSF) dynamics are thought to play a vital role in central nervous system (CNS) physiology. The objective of this study was to investigate the impact of spinal cord (SC) nerve roots (NR) on CSF dynamics. ...
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    Nonuniform Moving Boundary Method for Computational Fluid Dynamics Simulation of Intrathecal Cerebrospinal Flow Distribution in a Cynomolgus Monkey 

    Source: Journal of Biomechanical Engineering:;2017:;volume( 139 ):;issue: 008:;page 81005
    Author(s): Khani, Mohammadreza; Xing, Tao; Gibbs, Christina; Oshinski, John N.; Stewart, Gregory R.; Zeller, Jillynne R.; Martin, Bryn A.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: A detailed quantification and understanding of cerebrospinal fluid (CSF) dynamics may improve detection and treatment of central nervous system (CNS) diseases and help optimize CSF system-based delivery of CNS therapeutics. ...
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    Characterization of the Discrepancies Between Four Dimensional Phase Contrast Magnetic Resonance Imaging and In Silico Simulations of Cerebrospinal Fluid Dynamics 

    Source: Journal of Biomechanical Engineering:;2015:;volume( 137 ):;issue: 005:;page 51002
    Author(s): Heidari Pahlavian, Soroush; Bunck, Alexander C.; Loth, Francis; Shane Tubbs, R.; Yiallourou, Theresia; Robert Kroeger, Jan; Heindel, Walter; Martin, Bryn A.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The purpose of the present study was to compare subjectspecific magnetic resonance imaging (MRI)based computational fluid dynamics (CFD) simulations with timeresolved threedirectional (3D) velocityencoded phasecontrast MRI ...
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    Cerebrospinal Fluid Flow Impedance is Elevated in Type I Chiari Malformation 

    Source: Journal of Biomechanical Engineering:;2014:;volume( 136 ):;issue: 002:;page 21012
    Author(s): Shaffer, Nicholas; Martin, Bryn A.; Rocque, Brandon; Madura, Casey; Wieben, Oliver; Iskandar, Bermans J.; Dombrowski, Stephen; Luciano, Mark; Oshinski, John N.; Loth, Francis
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Diagnosis of Type I Chiari malformation (CMI) is difficult because the most commonly used diagnostic criterion, cerebellar tonsillar herniation (CTH) greater than 3–5 mm past the foramen magnum, has been found to have ...
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