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RISSimulating the Growth of TATA-Box Binding Protein-Associated Factor 15 Inclusions in Neuron Soma
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: To the best of the author's knowledge, this paper presents the first attempt to develop a mathematical model of the formation and growth of inclusions containing misfolded TATA-box binding protein associated factor 15 ...
Numerical and Analytical Simulation of the Growth of Amyloid-β Plaques
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Numerical and analytical solutions were employed to calculate the radius of an amyloid-β (Aβ) plaque over time. To the author's knowledge, this study presents the first model simulating the growth of Aβ plaques. Findings ...
Effects of Time-Dependent Adenosine Triphosphate Consumption Caused by Neuron Firing on Adenosine Triphosphate Concentrations in Synaptic Boutons Containing and Lacking a Stationary Mitochondrion
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The precise mechanism behind the supply of adenosine triphosphate (ATP) to approximately half of the presynaptic release sites in axons that lack a stationary mitochondrion is not fully understood. This paper presents a ...
Evaluating the Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A Novel Cellular-Level Criterion
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: A criterion characterizing the combined neurotoxicity of amyloid beta and tau oligomers is suggested. A mathematical model for calculating the value of this criterion during senile plaque and neurofibrillary tangle (NFT) ...
Dynein Dysfunction Prevents Maintenance of High Concentrations of Slow Axonal Transport Cargos at the Axon Terminal: A Computational Study
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Here, we report computational studies of bidirectional transport in an axon, specifically focusing on predictions when the retrograde motor becomes dysfunctional. We are motivated by reports that mutations in dynein-encoding ...