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    Mechanically Induced Deformation of Nuclei in the Tricuspid Valve Interstitial Cells: Experimental Measurements and Multi-scale Computational Simulation 

    Source: ASME Open Journal of Engineering:;2024:;volume( 003 ):;issue: 00:;page 31023-1
    Author(s): Pakzadmanesh, Mina; Salinas, Samuel D.; Thomas, Vineet S.; Jennings, Turner; DelCiello, Hayden; Vargas, Ana I.; Clarin, Julia; Amini, Rouzbeh
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: We examined the mechanical deformation of valve interstitial cells (VICs) in the anterior leaflet of the tricuspid valve and explored the relationship between the extracellular matrix (ECM) structure and cellular mechanics. ...
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