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RISFinite-Element Analysis of the Adhesion-Cytoskeleton-Nucleus Mechanotransduction Pathway During Endothelial Cell Rounding: Axisymmetric Model
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Endothelial cells possess a mechanical network connecting adhesions on the basal surface, the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway can deform the ...
Structural Mechanics Based Model for the Force-Bearing Elements Within the Cytoskeleton of a Cell Adhered on a Bed of Posts
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Mechanical forces play a vital role in the activities of cells and their interaction with biological and nonbiological material. Various experiments have successfully measured forces exerted by ...
Characterization of the Nuclear Deformation Caused by Changes in Endothelial Cell Shape
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: We investigated the mechanotransduction pathway in endothelial cells between their nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations in response to alterations ...