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RISComparison of Approaches to Quantify Arterial Damping Capacity From Pressurization Tests on Mouse Conduit Arteries
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Large conduit arteries are not purely elastic, but viscoelastic, which affects not only the mechanical behavior but also the ventricular afterload. Different hysteresis loops such as pressurediameter, pressureluminal ...
The Role of Collagen Synthesis in Ventricular and Vascular Adaptation to Hypoxic Pulmonary Hypertension
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Pulmonary arterial hypertension (PAH) is a rapidly fatal disease in which mortality is typically due to right ventricular (RV) failure. An excellent predictor of mortality in PAH is proximal pulmonary artery stiffening, ...
A Novel Paradigm for Engineering Education: Virtual Internships With Individualized Mentoring and Assessment of Engineering Thinking
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Engineering virtual internships are a novel paradigm for providing authentic engineering experiences in the firstyear curriculum. They are both individualized and accommodate large numbers of students. As we describe in ...
Increased Red Blood Cell Stiffness Increases Pulmonary Vascular Resistance and Pulmonary Arterial Pressure
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Patients with sickle cell anemia (SCD) and pulmonary hypertension (PH) have a significantly increased risk of sudden death compared to patients with SCD alone. Sickled red blood cells (RBCs) are stiffer, more dense, more ...
GBT440 Increases Hematocrit and Improves Biventricular Function in Berkeley Sickle Cell Disease Mice
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Sickle cell disease (SCD) is a hereditary blood disorder affecting millions of people in which red blood cells (RBCs) become sickled and lyse easily driven by polymerization of hemoglobin. Chronically, SCD causes anemia ...
Blood Pressure, Artery Size, and Artery Compliance Parallel Bone Size and Strength in Mice With Differing Ece1 Expression
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The recombinant congenic mouse strains HcB8 and HcB23 differ in femoral shape, size, and strength, with HcB8 femora being more gracile, more cylindrical, weaker, and having higher Young's modulus. In previous work, we ...
Low Cost Magnetic Resonance Imaging Compatible Stepper Exercise Device for Use in Cardiac Stress Tests
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Cardiovascular disease is the leading cause of death worldwide. Many cardiovascular diseases are better diagnosed during a cardiac stress test. Current approaches include either exercise or pharmacological stress ...
Multiscale Computational Analysis of Right Ventricular Mechanoenergetics
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Right ventricular (RV) failure, which occurs in the setting of pressure overload, is characterized by abnormalities in mechanical and energetic function. The effects of these cell- and tissue-level changes on organ-level ...