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    Hydrogel-Forming Microneedle Arrays for Sustained and Controlled Ocular Drug Delivery 

    Source: Journal of Engineering and Science in Medical Diagnostics and Therapy:;2020:;volume( 003 ):;issue: 004:;page 041003-1
    Author(s): Amer, Maher; Chen, Roland K.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Microneedles (MNs) provide a minimally invasive alternative to intravitreal injections and a promising means to sustainable ocular drug delivery. To optimize the sustained drug release profile and to ease the administration ...
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    Photo-Responsive Hydrogel Microneedles With Interlocking Control for Easy Extraction in Sustained Ocular Drug Delivery 

    Source: Journal of Engineering and Science in Medical Diagnostics and Therapy:;2021:;volume( 005 ):;issue: 001:;page 11001-1
    Author(s): Amer, Maher; Ni, Xiang; Xian, Ming; Chen, Roland K.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Microneedle arrays provide a minimally invasive platform for ocular drug delivery. Self-adhesive microneedle arrays, which incorporate barb-like locking features, have been developed to secure the array in place without ...
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    The Effect of Compression Force Uniformity on Bipolar Tissue Welding 

    Source: Journal of Manufacturing Science and Engineering:;2017:;volume( 139 ):;issue: 005:;page 54501
    Author(s): Li, Xiaoran; Borduin, Russel; Chen, Roland K.; Li, Wei
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Bipolar forceps are a type of electrosurgical device (ESD) widely used for tissue welding in modern surgeries. ESDs have many advantages over traditional surgical tools including reduced blood loss, improved efficiency, ...
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    Characterization of the Electrosurgical Tissue Joining Process Using Dynamic Impedance and Energy Efficiency 

    Source: Journal of Manufacturing Science and Engineering:;2019:;volume( 141 ):;issue: 005:;page 54502
    Author(s): Yang, Che-Hao; Li, Wei; Chen, Roland K.
    Publisher: American Society of Mechanical Engineers (ASME)
    Abstract: Electrosurgical tissue joining is an effective way to create hemostasis, especially in surgical procedures performed in the minimally invasive manner. The quality of tissue joints and potential thermal damages to the ...
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    Dynamic Impedance Monitoring for Large Diameter Vessel Sealing Using Bipolar Electrosurgery 

    Source: Journal of Medical Devices:;2020:;volume( 014 ):;issue: 002
    Author(s): Li, Xiaoran; Li, Wei; Yang, Che-Hao; Chen, Roland K.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Vessel sealing using bipolar electrosurgery is becoming a common practice in modern operating rooms. Despite all the advantages such as faster operation, less bleeding, and shorter postsurgery recovery time, side effects ...
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    A Review of State-of-the-Art on Enabling Additive Manufacturing Processes for Precision Medicine 

    Source: Journal of Manufacturing Science and Engineering:;2022:;volume( 145 ):;issue: 001:;page 10802-1
    Author(s): Awad, Atheer; Goyanes, Alvaro; Basit, Abdul W.; Zidan, Ahmed S.; Xu, Changxue; Li, Wei; Narayan, Roger J.; Chen, Roland K.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Precision medicine is an emerging healthcare delivery approach that considers variability between patients, such as genetic makeups, in contrast to the current one-size-fits-all approach that is designed to treat the average ...
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    Study of Insertion Force and Deformation for Suturing With Precurved NiTi Guidewire 

    Source: Journal of Biomechanical Engineering:;2015:;volume( 137 ):;issue: 004:;page 41004
    Author(s): Wang, Yancheng; Chen, Roland K.; Tai, Bruce L.; Xu, Kai; Shih, Albert J.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: This research presents an experimental study evaluating stomach suturing using a precurved nickel–titanium (NiTi) guidewire for an endoscopic minimally invasive obesity treatment. Precise path planning is critical for ...
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    Bipolar Electrosurgical Vessel Sealing Device With Compressive Force Monitoring 

    Source: Journal of Biomechanical Engineering:;2014:;volume( 136 ):;issue: 006:;page 61001
    Author(s): Chen, Roland K.; Chastagner, Matthew W.; Geiger, James D.; Shih, Albert J.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Bipolar electrosurgical vessel sealing is commonly used in surgery to perform hemostasis. The electrode compressive force is demonstrably an important factor affecting the vessel seal burst pressure, an index of the seal ...
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    Measurement and Modeling of Tissue Thermal Conductivity With Variable Water Content and Compression 

    Source: Journal of Heat Transfer:;2016:;volume( 138 ):;issue: 007:;page 74503
    Author(s): Chastagner, Matthew W.; Dodde, Robert E.; Shih, Albert J.; Li, Wei; Chen, Roland K.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The effects of water content and compression level on tissue thermal conductivity were studied. These effects are important in electrosurgery, as tissue is subjected to both compression and thermal heating. Ex vivo canine ...
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    The Needle With Lancet Point: Geometry for Needle Tip Grinding and Tissue Insertion Force 

    Source: Journal of Manufacturing Science and Engineering:;2013:;volume( 135 ):;issue: 004:;page 41010
    Author(s): Wang, Yancheng; Tai, Bruce L.; Chen, Roland K.; Shih, Albert J.
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The grinding procedure and setup, the cutting edge inclination and rake angles of the needle with lancet point (NLP), and the NLP tissue insertion force are investigated in this paper. The NLP is the most commonly used ...
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