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RISProbing the Effect of Random Adhesion Energy on Receptor Mediated Endocytosis With a Semistochastic Model
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The cellular uptake of a particle through receptormediated endocytosis involves specific binding between ligands on the particle surface and diffusive receptors on the cell membrane. Since the rupture force of these specific ...
Self Regulation of Motor Force Through Chemomechanical Coupling in Skeletal Muscle Contraction
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: It is intriguing how the mechanics of molecular motors is regulated to perform the mechanical work in living systems. In sharp contrast to the conventional wisdom, recent experiments indicated that motor force maintains ...
Modeling Deoxyribose Nucleic Acid as an Elastic Rod Inlaid With Fibrils
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: A classical view of the doublestranded deoxyribose nucleic acid (DNA) as an isotropic elastic rod fails to explain its high flexibility manifested in the formation of sharp loops that are essential in gene regulation and ...
Probing the Instability of a Cluster of Slip Bonds Upon Cyclic Loads With a Coupled Finite Element Analysis and Monte Carlo Method
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Cells are subjected to cyclic loads under physiological conditions, which regulate cellular structures and functions. Recently, it was demonstrated that cells on substrates reoriented nearly perpendicular to the stretch ...
Simplified Analysis for the Association of a Constrained Receptor to an Oscillating Ligand
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The stability of a bond cluster upon oscillated loads under physiological conditions is strongly regulated by the kinetics of association and dissociation of a single bond, which can play critical roles in cell–matrix ...
Switching Cellular Swirling Upon One-Way Torsional Drive
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: In understanding how a radially symmetrical actin cytoskeleton spontaneously evolves into a chiral system, here we construct a torsional clutch-filament model for one radial fiber. The model analysis indicates that when ...
Mobility of Alpha-Actinin Along Growing Actin Filaments Might Affect the Cellular Chirality
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Chirality is a widespread feature existing in nature and can be critical in the proper functions of some organisms. In our previous work, a rotational clutch-filament model for a radial fiber was built to reveal the critical ...
Numerical Simulation of Bubble Cluster Induced Flow by Three Dimensional Vortex in Cell Method
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The behavior of air bubble clusters rising in water and the induced flow field are numerically studied using a threedimensional twoway coupling algorithm based on a vortexincell (VIC) method. In this method, vortex elements ...
Changes of Extreme High Temperature by Global Warming in the Northern Hemisphere
Publisher: American Meteorological Society
Constitutive Theory for Direct Coupling of Molecular Frictions and the Viscoelasticity of Soft Materials
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: How to directly relate frictions at the level of a single molecular chain to the viscoelasticity of soft materials is intriguing. Here, we choose to investigate classical elastomers, where molecular frictions are known to ...