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RISMicroscale Fiber Network Alignment Affects Macroscale Failure Behavior in Simulated Collagen Tissue Analogs
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: A tissue's microstructure determines its failure properties at larger length scales, however, the specific relationship between microstructure and macroscopic failure in native and engineered soft tissues (such as capsular ...
2015 Summer Biomechanics, Bioengineering, and Biotransport Conference Student Paper Competition
Publisher: The American Society of Mechanical Engineers (ASME)
Investigation of Pathophysiological Aspects of Aortic Growth, Remodeling, and Failure Using a Discrete-Fiber Microstructural Model
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Aortic aneurysms are inherently unpredictable. One can never be sure whether any given aneurysm may rupture or dissect. Clinically, the criteria for surgical intervention are based on size and growth rate, but it remains ...
Conceptual Framework Development for a Double-Walled Aortic Stent-Graft to Manage Blood Pressure
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: A double-walled stent-graft (DWSG) design with a compressible gas layer was conceived with the goal of treating hypertension in patients receiving an aortic stent-graft. Early prototypes were developed to evaluate the ...
In Situ Lumbar Facet Capsular Ligament Strains Due to Joint Pressure and Residual Strain
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The lumbar facet capsular ligament, which surrounds and limits the motion of each facet joint in the lumbar spine, has been recognized as being mechanically significant and has been the subject of multiple mechanical ...
An Approach to Quantify Anisotropic Multiaxial Failure of the Annulus Fibrosus
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Tears in the annulus fibrosus (AF) of the intervertebral disk (IVD) occur due to multiaxial loading on the spine. However, most existing AF failure studies measure uniaxial stress, not the multiaxial stress at failure. ...
A Graphical Approach to Visualize and Interpret Biochemically Coupled Biomechanical Models
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The last decade has seen the emergence of progressively more complex mechanobiological models, often coupling biochemical and biomechanical components. The complexity of these models makes interpretation difficult, and ...
Residual Strain and Joint Pressurization Maintain Collagen Tension for On-Joint Lumbar Facet Capsular Ligaments
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Modeling the lumbar facet capsular ligament's (FCL) mechanical behavior under various physiological motions has often been a challenge due to limited knowledge about the on-joint in situ ligament state arising from attachment ...
Computational Analysis of Flow and Transport Suggests Reduced Oxygen Levels Within Intracranial Aneurysms, Especially in Individuals With Sickle-Cell Disease
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Sickle cell disease (SCD) is a genetic condition characterized by an abundance of sickle hemoglobin in red blood cells. SCD patients are more prone to intracranial aneurysms (ICA) compared to the general population, with ...
The Lumbar Facet Capsular Ligament Becomes More Anisotropic and the Fibers Become Stiffer With Intervertebral Disc and Facet Joint Degeneration
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Degeneration of the lumbar spine, and especially how that degeneration may lead to pain, remains poorly understood. In particular, the mechanics of the facet capsular ligament may contribute to low back pain, but the ...