| contributor author | Hankare | |
| contributor author | Priyanka;Agrawala | |
| contributor author | Ashish;Menezes | |
| contributor author | Viren | |
| date accessioned | 2022-08-18T12:51:28Z | |
| date available | 2022-08-18T12:51:28Z | |
| date copyright | 5/27/2022 12:00:00 AM | |
| date issued | 2022 | |
| identifier issn | 1932-6181 | |
| identifier other | med_016_03_034502.pdf | |
| identifier uri | http://yetl.yabesh.ir/yetl1/handle/yetl/4286981 | |
| description abstract | A shock wave-driven needle-free syringe was developed and tested for liquid jet delivery into an artificial skin model and porcine skin samples. The device could deliver an adequate volume of liquid to a depth sufficient for drug dissemination in skin samples. The device is equipped with a splash-proof conduit and a silencer for smooth operation. The concept is expected to minimize the pain of liquid injection by (a) minimally breaching the blood vessels in the skin, (b) reducing trauma and inflammation, and aiding in regeneration of the incised spot by the liquid of the jet, and (c) preserving most of the microcirculation system in the target, enabling an effective drug uptake. A theoretical model that predicts jet penetration into viscoelastic targets is derived and presented. A sound agreement has been observed between the experimental jet penetration depths and the corresponding theoretical predictions. The development can offer a cost-effective, minimally invasive health care solution for immunization and drug delivery. | |
| publisher | The American Society of Mechanical Engineers (ASME) | |
| title | High-Speed Jet Injector for Pharmaceutical Applications | |
| type | Journal Paper | |
| journal volume | 16 | |
| journal issue | 3 | |
| journal title | Journal of Medical Devices | |
| identifier doi | 10.1115/1.4054549 | |
| journal fristpage | 34502-1 | |
| journal lastpage | 34502-7 | |
| page | 7 | |
| tree | Journal of Medical Devices:;2022:;volume( 016 ):;issue: 003 | |
| contenttype | Fulltext | |
