Journal of Biomechanical Engineering: Recent submissions
Now showing items 901-920 of 5302
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Assessing the Disturbed Flow and the Transition to Turbulence in the Arteriovenous Fistula
(American Society of Mechanical Engineers (ASME), 2019)The arteriovenous fistula (AVF) is the main form of vascular access for hemodialysis patients, but its maintenance is very challenging. Its failure is mainly related to intimal hyperplasia (IH), leading to stenosis. The ... -
Changes in Shear Modulus of the Lumbar Multifidus Muscle During Different Body Positions
(American Society of Mechanical Engineers (ASME), 2019)Multifidus function is important for active stabilization of the spine, but it can be compromised in patients with chronic low back pain and other spine pathologies. Force production and strength of back muscles are often ... -
Simulated Tremor Propagation in the Upper Limb: From Muscle Activity to Joint Displacement
(American Society of Mechanical Engineers (ASME), 2019)Although tremor is the most common movement disorder, there are few noninvasive treatment options. Creating effective tremor suppression devices requires a knowledge of where tremor originates mechanically (which muscles) ... -
On the Influence of the Shoulder Kinematic Chain on Joint Kinematics and Musculotendon Lengths During Wheelchair Propulsion Estimated From Multibody Kinematics Optimization
(American Society of Mechanical Engineers (ASME), 2019)Multibody kinematic optimization is frequently used to assess shoulder kinematics during manual wheelchair (MWC) propulsion, but multiple kinematics chains are available. It is hypothesized that these different kinematic ... -
Functional Measures of Grip Strength and Gait Remain Altered Long-Term in a Rat Model of Post-Traumatic Elbow Contracture
(American Society of Mechanical Engineers (ASME), 2019)Post-traumatic joint contracture (PTJC) is a debilitating condition, particularly in the elbow. Previously, we established an animal model of elbow PTJC quantifying passive postmortem joint mechanics and histological changes ... -
Model First and Ask Questions Later: Confessions of a Reformed Experimentalist
(American Society of Mechanical Engineers (ASME), 2019)This paper is an invited perspective written in association with the awarding of the 2018 American Society of Mechanical Engineers Van C. Mow Medal. Inspired by Professor Mow's collaboration with Professor Michael Lai and ... -
Effects of Collagenase Type II on Vitreous Humor—An In Situ Rheological Study
(American Society of Mechanical Engineers (ASME), 2019)The purpose of this study is to quantify the impact of enzyme activity on the vitreous humor structure over time to understand the mechanical characteristics of the vitreous humor gel. Changes in the mechanical behavior ... -
The Effect of Oxidation on the Mechanical Response of Isolated Elastin and Aorta
(American Society of Mechanical Engineers (ASME), 2019)Oxidation of aorta by hydroxyl radicals produces structural changes in arterial proteins like elastin and collagen. This in turn results in change in the mechanical response of aorta. In this paper, a thermodynamically ... -
Muscle-Tendon Unit Parameter Estimation of a Hill-Type Musculoskeletal Model Based on Experimentally Obtained Subject-Specific Torque Profiles
(American Society of Mechanical Engineers (ASME), 2019)The aim of this study was to generate a subject-specific musculoskeletal muscle model, based on isometric and isovelocity measurements of the whole lower extremity. A two-step optimization procedure is presented for ... -
Deciphering the “Art” in Modeling and Simulation of the Knee Joint: Overall Strategy
(American Society of Mechanical Engineers (ASME), 2019)Recent explorations of knee biomechanics have benefited from computational modeling, specifically leveraging advancements in finite element analysis and rigid body dynamics of joint and tissue mechanics. A large number of ... -
MMP12 Deletion Preferentially Attenuates Axial Stiffening of Aging Arteries
(American Society of Mechanical Engineers (ASME), 2019)Arterial stiffening is a hallmark of aging, but how aging affects the arterial response to pressure is still not completely understood, especially with regard to specific matrix metalloproteinases (MMPs). Here, we performed ... -
ANNUAL SPECIAL ISSUE “Biomechanical Engineering—2018 Year in Review”
(American Society of Mechanical Engineers (ASME), 2019) -
Bridging Finite Element and Machine Learning Modeling: Stress Prediction of Arterial Walls in Atherosclerosis
(American Society of Mechanical Engineers (ASME), 2019)Finite element and machine learning modeling are two predictive paradigms that have rarely been bridged. In this study, we develop a parametric model to generate arterial geometries and accumulate a database of 12,172 2D ... -
Numerical Investigation of Turbulence in Abdominal Aortic Aneurysms
(American Society of Mechanical Engineers (ASME), 2019)Computational fluid dynamics (CFD) is a powerful method to investigate aneurysms. The primary focus of most investigations has been to compute various hemodynamic parameters to assess the risk posed by an aneurysm. Despite ... -
Cholesterol-Dependent Modulation of Stem Cell Biomechanics: Application to Adipogenesis
(American Society of Mechanical Engineers (ASME), 2019)Cell mechanics has been shown to regulate stem cell differentiation. We have previously reported that altered cell stiffness of mesenchymal stem cells can delay or facilitate biochemically directed differentiation. One of ... -
In Vivo Layer-Specific Mechanical Characterization of Porcine Stomach Tissue Using a Customized Ultrasound Elastography System
(American Society of Mechanical Engineers (ASME), 2019)This paper presents in vivo mechanical characterization of the muscularis, submucosa, and mucosa of the porcine stomach wall under large deformation loading. This is particularly important for the development of gastrointestinal ... -
In Silico Performance of a Recellularized Tissue-Engineered Transcatheter Aortic Valve
(American Society of Mechanical Engineers (ASME), 2019)Commercially available heart valves have many limitations, such as a lack of remodeling, risk of calcification, and thromboembolic problems. Many state-of-the-art tissue-engineered heart valves (TEHV) rely on recellularization ... -
Computational Modeling of Developing Cartilage Using Experimentally Derived Geometries and Compressive Moduli
(American Society of Mechanical Engineers (ASME), 2019)During chondrogenesis, tissue organization changes dramatically. We previously showed that the compressive moduli of chondrocytes increase concomitantly with extracellular matrix (ECM) stiffness, suggesting cells were ... -
A Review of Impact Testing Methods for Headgear in Sports: Considerations for Improved Prevention of Head Injury Through Research and Standards
(American Society of Mechanical Engineers (ASME), 2019)Standards for sports headgear were introduced as far back as the 1960s and many have remained substantially unchanged to present day. Since this time, headgear has virtually eliminated catastrophic head injuries such as ... -
Flow Dynamics in the Aortic Arch and Its Effect on the Arterial Input Function in Cardiac Computed Tomography
(American Society of Mechanical Engineers (ASME), 2019)The arterial input function (AIF)—time-density curve (TDC) of contrast at the coronary ostia—plays a central role in contrast enhanced computed tomography angiography (CTA). This study employs computational modeling in a ...