Journal of Biomechanical Engineering: Recent submissions
Now showing items 601-620 of 5302
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Mechanobiology of Pulmonary Diseases: A Review of Engineering Tools to Understand Lung Mechanotransduction
(The American Society of Mechanical Engineers (ASME), 2021)Cells within the lung micro-environment are continuously subjected to dynamic mechanical stimuli which are converted into biochemical signaling events in a process known as mechanotransduction. In pulmonary diseases, the ... -
Interpretation of Experimental Data is Substantial for Constitutive Characterization of Arterial Tissue
(The American Society of Mechanical Engineers (ASME), 2021)The paper aims at evaluation of mechanical tests of soft tissues and creation of their representative stress–strain responses and respective constitutive models. Interpretation of sets of experimental results depends highly ... -
Carpal Arch Changes in Response to Thenar Muscle Loading
(The American Society of Mechanical Engineers (ASME), 2021)This study investigated the biomechanical effects of thenar muscles (abductor pollicis brevis (APB), superficial head of flexor pollicis brevis (sFPB), opponens pollicis (OPP)) on the transverse carpal ligament formed ... -
Architecture-Dependent Mechano-Adaptation in Single Vascular Smooth Muscle Cells
(The American Society of Mechanical Engineers (ASME), 2021)Arteries grow and remodel following mechanical perturbation. Vascular smooth muscle cells (VSMCs) within the artery undergo hyperplasia, hypertrophy, or change their contractility following sustained changes in loading. ... -
Displacement Error Propagation From Embedded Markers to Brain Strain
(The American Society of Mechanical Engineers (ASME), 2021)Head injury model validation has evolved from against pressure to relative brain–skull displacement, and more recently, against marker-based strain. However, there are concerns on strain data quality. In this study, we ... -
Biomechanical Analysis of Head Subjected to Blast Waves and the Role of Combat Protective Headgear Under Blast Loading: A Review
(The American Society of Mechanical Engineers (ASME), 2021)Blast-induced traumatic brain injury (bTBI) is a rising health concern of soldiers deployed in modern-day military conflicts. For bTBI, blast wave loading is a cause, and damage incurred to brain tissue is the effect. There ... -
Layer-Specific Residual Deformations and Their Variation Along the Human Aorta
(The American Society of Mechanical Engineers (ASME), 2021)This study described the regional distribution of layer-specific residual deformations in fifteen human aortas collected during autopsy. Circumferentially and axially cut strips of standardized dimensions from the anterior ... -
On the Three-Dimensional Correlation Between Myofibroblast Shape and Contraction
(The American Society of Mechanical Engineers (ASME), 2021)Myofibroblasts are responsible for wound healing and tissue repair across all organ systems. In periods of growth and disease, myofibroblasts can undergo a phenotypic transition characterized by an increase in extracellular ... -
Model-Aided Design of a Rear-Impact Collision Testing System for In Vivo Investigations
(The American Society of Mechanical Engineers (ASME), 2021)A collision testing device used to simulate rear-end impacts on human volunteers was developed and validated. The testing device was designed using impact parameters obtained from real crash-test-derived vehicle-to-vehicle ... -
Evaluation of the Kinematic Biofidelity and Inter-Test Repeatability of Global Accelerations and Brain Parenchyma Pressure for a Head–Brain Physical Model
(The American Society of Mechanical Engineers (ASME), 2021)Head surrogates are widely used in biomechanical research and headgear assessment. They are designed to approximate the inertial and mechanical properties of the head and are instrumented to measure global head kinematics. ... -
Finite Element Implementation of Biphasic-Fluid Structure Interactions in febio
(The American Society of Mechanical Engineers (ASME), 2021)In biomechanics, solid–fluid mixtures have commonly been used to model the response of hydrated biological tissues. In cartilage mechanics, this type of mixture, where the fluid and solid constituents are both assumed to ... -
Blood Flow Velocimetry in a Microchannel During Coagulation Using Particle Image Velocimetry and Wavelet-Based Optical Flow Velocimetry
(The American Society of Mechanical Engineers (ASME), 2021)This article describes novel measurements of the velocity of whole blood flow in a microchannel during coagulation. The blood is imaged volumetrically using a simple optical setup involving a white light source and a ... -
Optical Coherence Tomography-Based Patient-Specific Residual Multi-Thrombus Coronary Plaque Models With Fluid–Structure Interaction for Better Treatment Decisions: A Biomechanical Modeling Case Study
(The American Society of Mechanical Engineers (ASME), 2021)Intracoronary thrombus from plaque erosion could cause fatal acute coronary syndrome (ACS). A conservative antithrombotic therapy has been proposed to treat ACS patients in lieu of stenting. It is speculated that the ... -
A Computational Fluid–Structure Interaction Study for Carotids With Different Atherosclerotic Plaques
(The American Society of Mechanical Engineers (ASME), 2021)Atherosclerosis is a systemic disease that leads to accumulation of deposits, known as atherosclerotic plaques, within the walls of the carotids. In particular, three types of plaque can be distinguished: soft, fibrous, ... -
Computational Fluid Dynamics Study of Cerebral Thromboembolism Risk in Ventricular Assist Device Patients: Effects of Pulsatility and Thrombus Origin
(The American Society of Mechanical Engineers (ASME), 2021)This study investigates the hypothesis that by surgically manipulating the outflow graft (OG) implantation during ventricle assist device placement, it may be possible to reduce the risk of cerebral embolism. We investigate ... -
In Silico Finite Element Analysis of the Foot Ankle Complex Biomechanics: A Literature Review
(The American Society of Mechanical Engineers (ASME), 2021)Computational approaches, especially finite element analysis (FEA), have been rapidly growing in both academia and industry during the last few decades. FEA serves as a powerful and efficient approach for simulating real-life ... -
Footwear and Elevated Heel Influence on Barbell Back Squat: A Review
(The American Society of Mechanical Engineers (ASME), 2021)The back squat is one of the most effective exercises in strengthening the muscles of the lower extremity. Understanding the impact of footwear has on the biomechanics is imperative for maximizing the exercise training ... -
A Novel In Vitro and In Silico System for Analyzing Complex Mechanobiological Behavior of Chondrocytes in Three-Dimensional Hydrogel Constructs
(The American Society of Mechanical Engineers (ASME), 2021)Physiological loading is essential for the maintenance of articular cartilage through the regulation of tissue remodeling. To correctly understand the behavior of chondrocytes in their native environment, cell stimulating ... -
The Design and Validation of a Low-Cost Foot Measurement System
(The American Society of Mechanical Engineers (ASME), 2021)It is estimated that approximately 40% of the population suffers from abnormal foot posture, specifically high arched or low arched feet. While the evaluation of foot posture can involve many aspects, it commonly requires ... -
Unloaded Organ Culturing Has a Detrimental Effect on the Axial Mechanical Properties of the Intervertebral Disc
(The American Society of Mechanical Engineers (ASME), 2021)Healthy function of intervertebral discs (IVDs) depends on their tissue mechanical properties. Native cells embedded within IVD tissues are responsible for building, maintaining, and repairing IVD structures in response ...