| contributor author | Narasimhan, Arunn | |
| contributor author | Joseph, Ajith | |
| date accessioned | 2017-05-09T01:20:04Z | |
| date available | 2017-05-09T01:20:04Z | |
| date issued | 2015 | |
| identifier issn | 0022-1481 | |
| identifier other | ht_137_12_121007.pdf | |
| identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/158599 | |
| description abstract | A numerical model for transdermal drug delivery (TDD) has been developed by treating skin as a composite, dynamic, porous medium. Governing unsteady mass transport equations in porous medium was solved for different cases for up to a period of drugpatch application of 10 hrs. The effects of cell migration and anisotropic diffusive properties of stratum corneum (SC) on TDD are analyzed. Each of the above factors and their combination are found to significantly affect TDD. The cell migration in SC decreases the predicted amount of drug considerably. Their combined effect in TDD helped in identifying four distinct regimes of pharmacological as well as engineering importance within the domain. | |
| publisher | The American Society of Mechanical Engineers (ASME) | |
| title | Porous Medium Modeling of Combined Effects of Cell Migration and Anisotropicity of Stratum Corneum on Transdermal Drug Delivery | |
| type | Journal Paper | |
| journal volume | 137 | |
| journal issue | 12 | |
| journal title | Journal of Heat Transfer | |
| identifier doi | 10.1115/1.4030923 | |
| journal fristpage | 121007 | |
| journal lastpage | 121007 | |
| identifier eissn | 1528-8943 | |
| tree | Journal of Heat Transfer:;2015:;volume( 137 ):;issue: 012 | |
| contenttype | Fulltext | |
