On the Infusion of a Therapeutic Agent Into a Solid Tumor Modeled as a Poroelastic Medium

Abstract

The direct infusion of an agent into a solid tumor, modeled as a spherical poroelastic material with anisotropic dependence of the tumor hydraulic conductivity upon the tissue deformation, is treated both by solving the coupled fluid/elastic equations, and by expressing the solution as an asymptotic expansion in terms of a small parameter, ratio between the driving pressure force in the fluid system, and the elastic properties of the solid. Results at order one match almost perfectly the solutions of the full system over a large range of infusion pressures. Comparison with experimental results is acceptable after the hydraulic conductivity of the medium is properly calibrated. Given the uncertain estimates of some model constants, the order zero solution of the expansion, for which fluid and porous matrix are decoupled, yields acceptable values and trends for all the physical fields of interest, rendering the coupled analysis (in the limit of small displacements) of little use. When the deformation of the tissue becomes large nonlinear elasticity theory must be resorted to.