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RISAgent Based Modeling Traction Force Mediated Compaction of Cell Populated Collagen Gels Using Physically Realistic Fibril Mechanics
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Agentbased modeling was used to model collagen fibrils, composed of a string of nodes serially connected by links that act as Hookean springs. Bending mechanics are implemented as torsional springs that act upon each set ...
An Agent-Based Discrete Collagen Fiber Network Model of Dynamic Traction Force-Induced Remodeling
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Microstructural properties of extracellular matrix (ECM) promote cell and tissue homeostasis as well as contribute to the formation and progression of disease. In order to understand how microstructural properties influence ...
Complex Matrix Remodeling and Durotaxis Can Emerge From Simple Rules for Cell Matrix Interaction in Agent Based Models
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Using a topdown approach, an agentbased model was developed within NetLogo where cells and extracellular matrix (ECM) fibers were composed of multiple agents to create deformable structures capable of exerting, reacting ...