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RISThe Role of Collagen Synthesis in Ventricular and Vascular Adaptation to Hypoxic Pulmonary Hypertension
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Pulmonary arterial hypertension (PAH) is a rapidly fatal disease in which mortality is typically due to right ventricular (RV) failure. An excellent predictor of mortality in PAH is proximal pulmonary artery stiffening, ...
Increased Red Blood Cell Stiffness Increases Pulmonary Vascular Resistance and Pulmonary Arterial Pressure
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Patients with sickle cell anemia (SCD) and pulmonary hypertension (PH) have a significantly increased risk of sudden death compared to patients with SCD alone. Sickled red blood cells (RBCs) are stiffer, more dense, more ...
GBT440 Increases Hematocrit and Improves Biventricular Function in Berkeley Sickle Cell Disease Mice
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Sickle cell disease (SCD) is a hereditary blood disorder affecting millions of people in which red blood cells (RBCs) become sickled and lyse easily driven by polymerization of hemoglobin. Chronically, SCD causes anemia ...