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RISAgent Based Modeling Traction Force Mediated Compaction of Cell Populated Collagen Gels Using Physically Realistic Fibril Mechanics
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Agentbased modeling was used to model collagen fibrils, composed of a string of nodes serially connected by links that act as Hookean springs. Bending mechanics are implemented as torsional springs that act upon each set ...
An Agent-Based Discrete Collagen Fiber Network Model of Dynamic Traction Force-Induced Remodeling
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Microstructural properties of extracellular matrix (ECM) promote cell and tissue homeostasis as well as contribute to the formation and progression of disease. In order to understand how microstructural properties influence ...
Complex Matrix Remodeling and Durotaxis Can Emerge From Simple Rules for Cell Matrix Interaction in Agent Based Models
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Using a topdown approach, an agentbased model was developed within NetLogo where cells and extracellular matrix (ECM) fibers were composed of multiple agents to create deformable structures capable of exerting, reacting ...
Paired Pressure–Volume Loop Analysis and Biaxial Mechanical Testing Characterize Differences in Left Ventricular Tissue Stiffness of Volume Overload and Angiotensin-Induced Pressure Overload Hearts
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Pressure overload (PO) and volume overload (VO) of the heart result in distinctive changes to geometry, due to compensatory structural remodeling. This remodeling potentially leads to changes in tissue mechanical properties. ...
Biomechanics and Mechanobiology of Saphenous Vein Grafts
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Within several weeks of use as coronary artery bypass grafts (CABG), saphenous veins (SV) exhibit significant intimal hyperplasia (IH). IH predisposes vessels to thrombosis and atherosclerosis, the two major modes of vein ...