Abstract: Nanoparticle-mediated drug delivery may be a promising alternative to traditional chemotherapy of high systemic toxicity. Tumor tissue architecture poses a challenge to delivery of nanoparticles. Small and spherical ...

Abstract: Previous work in air transportation system-of-systems (ATSoSs) design optimization considered integrated aircraft sizing, fleet allocation, and route network configuration. The associated nested multidisciplinary formulation ...

Abstract: Nanoparticle (NP)-based drug delivery is a promising method to increase the therapeutic index of anticancer agents with low median toxic dose. The delivery efficiency, corresponding to the fraction of the injected NPs that ...

Abstract: Nanoparticle drug delivery better targets neoplastic lesions than free drugs and thus has emerged as a safer form of cancer therapy. Nanoparticle design variables are important determinants of efficacy as they influence ...