Abstract: In this work, a novel analytical framework is proposed for the riskbased design of complex engineering systems. The risk baseddesign process is the reverse process of risk propagation that entails the optimum allocation ...

Abstract: In gas turbine applications, forced vibrations of turbine blades under resonant—or nearly resonant—conditions are undesirable. Usually in airfoil design procedures, at least the first three blade modes are required to ...

Abstract: The synthesis of functional molecular linkages is constrained by difficulties in fabricating nanolinks of arbitrary shapes and sizes. Thus, classical mechanism synthesis methods, which assume the ability to manufacture any ...

Abstract: Orthotic treatments for knee osteoarthritis (OA) typically rely on simple mechanisms such as three-point bending straps and single-pin hinges. These commonly prescribed braces cannot treat bicompartmental knee OA, do not ...

Abstract: Natural nanomechanisms such as capillaries, neurotransmitters, and ion channels play a vital role in the living systems. But the design principles developed by nature through evolution are not well understood and, hence, ...

Abstract: A reliable prediction of threedimensional (3D) protein structures from sequence data remains a big challenge due to both theoretical and computational difficulties. We have previously shown that our kinetostatic compliance ...